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Programme • Poster programme • Poster information
Sunday, 16 October 2011 |
|
| 10.30 - 12.00 | Author Workshop |
| 13.00 - 15.00 | Session 1 - DNA Repair Machines Session Chair: Tom Blundell |
| 13.00 - 13.05 | Welcome by Elsevier |
| 13.05 - 13.15 | Introduction by Conference Chairs: Tom Blundell and John Tainer |
| 13.15 - 13.50 | [K01] Setting the scene: DNA repair complexes and a dawn for structural and mechanistic systems biology John Tainer, The Scripps Research Institute, USA |
| 13.50 - 14.25 | [K02] Molecular machines of double-strand break repair: What they look like and how they work Claire Wyman, Erasmus Medical Center, The Netherlands |
| 14.25 - 15.00 | [K03] Structural architecture and remodeling of modular multi-domain proteins in DNA repair machines Walter Chazin, Vanderbilt University, USA |
| 15.00 - 15.30 | Refreshment Break |
| 15.30 - 17.40 | Session 2 - Chromatin & Damage Responses Session Chair: Laurence Pearl |
| 15.30 - 16.05 | [K04] The role of the RSC chromatin remodelling complex in DNA damage responses Jessica Downs, University of Sussex, UK |
| 16.05 - 16.40 | [K05] Structure and mechanism of the INO80 complex Dale Wigley, The Institute of Cancer Research, UK |
| 16.40 - 17.00 | [O2.1] Chromatin dynamics revealed by time-lapse AFM Y. Lyubchenko*, L. Shlyakhtenko, A. Miyagi; University of Nebraska Medical Center, USA |
| 17.00 - 17.20 | [O2.2] Lesion-induced pairing of sister chromatids enables homologous repair of double-strand DNA breaks in bacteria N. Shechter, A. Weiner, A. Minsky*; The Weizmann Institute of Science, Israel |
| 17.20 - 17.40 | [O2.3] Structure of TDG bound to substrate analogue informs its catalytic mechanism and its weak G•T repair activity A. Maiti, E. Pozharski, A.C. Drohat*; University of Maryland School of Medicine, USA |
| 18.00 - 19.30 | Welcome reception and poster session 1 |
Monday, 17 October 2011 |
|
| 8.30 - 10.40 | Session 3 - DNA Remodeling & Fidelity Session Chair: Jessica Downs |
| 8.30 - 9.05 | [K06] Recognition and repair of DNA single-strand breaks Laurence Pearl, University of Sussex, UK |
| 9.05 - 9.40 | [K07] Towards damage verification in nucleotide excision repair Caroline Kisker, University of Würzburg- Rudolf Virchow Center, Germany |
| 9.40 - 10.00 | [O3.1] The UvrA•UvrB DNA damage sensor: Structure and mechanism D. Jeruzalmi*, D. Pakotiprapha, M. Samuels, K. Shen, J. Hu; Harvard University, USA |
| 10.00 - 10.20 | [O3.2] Structure of REV7 in complex with a REV3 fragment and structural implication of the interaction between DNA polymerase ζ and REV1 H. Hashimoto*¹, K. Hara, Y. Murakumo², S. Kobayashi³, S. Takeda³, M. Sato¹; ¹Yokohama City University, Japan, ²Nagoya University, Japan, ³Kyoto University, Japan |
| 10.20 - 10.40 | [O3.3] Characterization of the structure and dynamics of hMutSα- and hMutSα-hMutLα-heteroduplex complexes using AFM and single molecule fluorescence D. Burke¹, V. DeRocco¹, B. Wang¹, C. Du², P. Hsieh², D.A. Erie*¹; ¹University of North Carolina, USA, ²NIDDK, NIH, USA |
| 10.40 - 11.10 | Refreshment Break |
| 11.10 - 13.00 | Session 4 - Replication & Mismatch Repair Session Chair: Wei Yang |
| 11.10 - 11.45 | [K08] Molecular insights into the function of proteins important for DNA replication and repair Luca Pellegrini, University of Cambridge UK |
| 11.45 - 12.20 | [K09] Molecular insight into polymerase fidelity Lars C. Pedersen, NIH,USA |
| 12.20 - 12.55 | [K10] Genesis and repair of DNA replication errors Lorena Beese, Duke University, USA |
| 13.00 - 14.30 | Lunch + Meet the Professors Walter Chazin, Loreena Beese, Luca Pellegrini, Caroline Kiser and Jessica Downs |
| 14.30 - 16.00 | Poster Session 2 + refreshments |
| 16.00 - 17.40 | Session 5 - Repair Mechanisms & Disease Session: Oscar Llorca |
| 15.30 - 16.05 | [K11] Conformational dynamics of the Mre11-Rad50-Nbs1 complex in DNA double-strand break repair Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany |
| 16.05 - 16.40 | [K12] DNA repair enzymes: Structure, chemistry and disease Wei Yang, NIH,USA |
| 16.40 - 17.00 | [O5.1] DNA replication and repair enzymes as targets for antibacterial drug discovery G. Sanyal, AstraZeneca R&D Boston, USA |
| 17.00 - 17.20 | [O5.2] Defining key molecular mechanisms of the sumoylation pathway functioning to regulate DNA repair J.J.P. Perry*, J. Prudden, A.S. Arvai, C. Hitomi, J.A. Tainer, M.N. Boddy; The Scripps Research Institute, USA |
| 17.20 - 17.40 | [O5.3] Self-catalyzed site-specific DNA depurination and the origin of mutations in disease-related genes J.R. Fresco*, O. Amosova; Princeton University, USA |
| 19.00 - 22.00 | Conference dinner |
Tuesday, 18 October 2011 |
|
| 8.30 - 10.40 | Session 6 - Processing Breaks and Forks Session Chair: Luca Pellegrini |
| 8.30 - 9.05 | [K13] Structural Biology of Double-Strand Breaks Repair in both Non-Homologous End Joining and Homologous Recombination Pathways Tom Blundell, University of Cambridge, UK |
| 9.05 - 9.40 | [K14] DNA double strand break repair: Assembly of a functional repair complex Murray Junop, McMaster University, Canada |
| 9.40 - 10.00 | [O6.1] Structural characterization of the filaments formed by the Xrcc4-Cernunnos/XLF complex by crystallography and electron microscopy J.B. Charbonnier*¹,², V. Ropars¹,², P. Drevet¹,², P. Legrand³, S. Baconnais², J. Amram¹,², et al; ¹CEA, France, ²CNRS, France, ³Synchrotron SOLEIL, France |
| 10.00 - 10.20 | [O6.2] Molecular architecture and switching mechanism of DNA replication fork complex as revealed by single particle analysis K. Mayanagi, Kyushu University, Japan |
| 10.20 - 10.40 | [O6.3] Structural basis of aprataxin DNA ligase proofreading with insights into AOA1 neurodegenerative disease R.S. Williams, NIH/NIEHS, USA |
| 10.40 - 11.10 | Refreshment Break |
| 11.10 - 13.00 | Session 7 - Healing Ends Session Chair: Stephen Smerdon |
| 11.10 - 11.45 | [K15] Mechanisms of 5’ and 3’ DNA recognition by the DNA repair enzyme, polynucleotide kinase/phosphatase Mark Glover, University of Alberta, Canada |
| 11.45 - 12.20 | [K16] Many ways to make ends meet: Polymerase-mediated orchestration of DNA double-strand break repair Aidan Doherty, University of Sussex, UK |
| 12.20 - 12.55 | [K17] Structural chemical biology of DNA end joining Tom Ellenberger, Washington University School of Medicine, USA |
| 13.00 - 13.30 | Sofa Session: Pathway interactions & possible chemical controls |
| 13.00 - 14.30 | Poster Session 3 + Lunch |
| 14.30 - 16.00 | Session 8 - Damage Signaling Session Chair: Claire Wyman |
| 14.30 - 14.40 | Poster Award Ceremony |
| 14.40 - 15.15 | [K18] Scaffolds and adaptors in DNA-damage response signalling Stephen Smerdon, MRC National Institute for Medical Research, UK |
| 15.15 - 15.50 | [K19] Molecular architecture and regulation of the large PI3K-like protein kinases (PIKKs) Oscar Llorca, Spanish National Research Council, Spain |
| 15.50 - 16.00 | Closing Remarks Tom Blundell |
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Chairmen's Address
Tom Blundell John Tainer
Tom Blundell John Tainer
