Presentation:
Molecular Insight into Polymerase Fidelity

Bio

Lars Pedersen heads the Structure and Function group at the NIEHS/NIH. In collaboration with the Kunkel and Wilson laboratories at the NIEHS, his work has focused on understanding the mechanism by which the DNA repair X family polymerases carry out the nucleotidyltransferase reaction for correct/incorrect base incorporation as well as with damaged substrates. In addition he is interested in tailoring enzymes involved in heparan sulfate biosynthesis for the production of homogeneous therapeutic anticoagulants. Lars obtained a BS in chemistry from the University of North Carolina at Chapel Hill and his PhD in biochemistry from the University of Washington in Seattle.

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