Presentation:
Molecular architecture and regulation of the large PI3K-like protein kinases (PIKKs)

Bio

Oscar Llorca obtained his Ph.D. in Molecular Biology (1992-1996) at the National Centre for Biotechnology (CNB) in Madrid (Spain) working on the structure of GroEL chaperonin complexes using electron microscopy. As a post-doc in Madrid (1996-2000) he performed influential work on the structural characterization of actin and tubulin folding mediated by the eukaryotic cytosolic chaperonin.  From 2000 to 2002 he worked at the Chester Beatty Laboratories (Institute of Cancer Research, London, UK), in the group of Keith Willison and in collaboration with the group of Alan Ashworth in the structural characterization of DNA repair complexes. He returned to Spain in June 2002 as team leader at the Centre for Biological Research (CIB) of the Spanish National Research Council, where he set up his own group dedicated to the structural and functional analysis of large macromolecular complexes using electron microscopy. Currently, the group leaded by Oscar Llorca devotes to the functional and structural understanding of large macromolecular machines, involved in (a) DNA and RNA transactions (DNA repair, DNA replication and mRNA decay) and (b) complexes that regulate the complement in the innate immune system.

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