Presentation:
Structural Chemical Biology of DNA End Joining

Bio

Tom Ellenberger studied veterinary medicine at Iowa State University before pursuing a Ph.D. degree in Pharmacology at Harvard Medical School, working on the genetics of multidrug resistant protozoan parasites. During postdoctoral studies at Harvard University, he determined several crystal structures of transcription factors bound to DNA, including yeast GCN4 and the mammalian E47 protein. He began his independent career on the faculty of Harvard Medical School, studying the structures and mechanisms of DNA replication, repair, and recombination proteins. In 2006, Dr. Ellenberger moved to Washington University School of Medicine in Saint Louis where he is Chair of the Department of Biochemistry and Molecular Biophysics. His group is using structure-based design to develop small molecule effectors of DNA damage responses, as research tools and potential therapeutics.

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